La Passe FC (Sey) – Mamelodi Sundowns (Rsa) 0-7 1-8
ASEC Mimosas (Civ) – Horoya AC (Gui) 0-1 1-1
ASKO de Kara (Tog) – JS Kabylie (Alg) 1-2 1-1
Djoliba AC (Mli) – CR Belouizdad (Alg) 2-1 0-2
Young Africans SC (Tan) – Al Hilal (Sdn) 1-1 0-1
Flambeau du Centre (Bdi) – Zamalek SC (Egy) 0-1 1-5
Cape Town City (Rsa) – Petro Atletico (Ang) 0-3 0-1
Primeiro de Agosto (Ang) – Simba SC (Tan) 1-3 0-1
Royal Leopards (Esw) – Coton Sport (Cmr) 1-1 1-2
Rail Club Kadiogo (Bfa) – AS Vita Club (Rdc) 0-0 (le 19/10)
Al Merriekh (Sdn) – Al Ahli Tripoli (Lby) 2-0 1-3
Rivers United (Ngr) – WAC Casablanca (Mar) 2-1 0-6
Plateau United (Ngr) – Espérance Tunis (Tun) 2-1 0-1
ASN NIGELEC Nig) – Raja Casablanca (Mar) 0-2 0-1
US Monastir (Tun) – Al Ahly (Egy) 0-1 0-3
Vipers SC (Uga) – TP Mazembe (Rdc) 0-0 0-0 (4-2pen)
